Updated: October 2022 My name is Elizabeth and I will never have an easy disease to diagnose. It took several years ro get my diagnosis. I've taken a few different drugs, but none of them truly worked out for me. Methotrexate didn't work well. But Leflunomide changed my life. Not so much arthritis-wise, as I responded well. However, I began experiencing possible thyroid and kidney problems while taking leflunomide. I have calcium crystals in my kidneys, which could later become stones. As my mum says, "I'm sparkling on the inside." We found this as blood was found in my urine many times. I also had to do a twenty-four hour urine sample, which is when you collect all the urine you produce in twenty-four hours. It really is quite embarrassing walking into the hospital with a container of your own urine, but it's worth it. I'm currently seeing a specialist for this problem and we are taking care of it right now by discontinuing leflunomide and lett
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